中药复方治疗痛经用药规律(一)
详细内容
【摘要】 收集近20年来治疗痛经的中药复方176首，建立中药复方数据库，用频率分析法分析药物的使用比例、使用频率和剂量；用单指标和多指标的多因子线性逐步回归统计学方法，筛选决定单指标和多指标的主要药物，建立回归方程，预测复方的临床疗效。得出在173种中药中，活血化瘀类中药和理气类中药的使用比例和使用频率最高；统计出常用的20味中药的剂量区间；建立单指标和多指标的线性逐步回归方程，筛选出决定单指标和多指标中各指标的主要药物，并用单指标回归方程检验了176首处方的总有效率，其绝对误差在4%以内的有167首，占总处方的94.89%。提示活血理气类药物为最常用的药物；建立的逐步回归方程能较为精确地预测复方治疗痛经的临床疗效。
【关键词】 痛经 中药 复方 回归分析
Abstract: pound traditional Chinese medicine database was established by collecting 176 pound formulas for dysmenorrhea in the last twenty years. The proportion and frequency of herbal medicine were analyzed and the main herbs with mono?target or multi?target in the pound formulas were selected with simple and multiple linear regression. The linear regression equations were listed and the clinical effects of the pound formulas were eva luated. Of 173 herbs used in the pound formulas, the proportion and frequency of the herbs for activating blood and transforming stasis and regulating qi flow were high in the application. The dosage interval for 20 herbs in mon use was estimated. Main herbs with mono?target or multi?target used in the pound formulas were selected with simple and multiple linear regression. The total effectiveness rate of the 176 pound formulas was tested with simple linear regression, and 167 pound formulas (94.84 % of the total) had the absolute error less than 4%. Herbs for activating blood and transforming stasis and regulating qi flow are most monly used in treatment of dysmenorrhea. Clinical effects of the pound formulas could be forecast with stepwise regression equation.
Keywords: dysmenorrhea; Chinese herbal drugs; pounds (traditional Chinese drugs); regression analysis
通过检索重庆维普数据库，收集了近20年来治疗原发性痛经及继发性痛经的中药复方176首，用频率分析法分析用药的使用比例、使用频率和剂量；用单指标和多指标的多因子线性逐步回归统计学方法，建立回归方程，筛选决定单指标和多指标中各指标的主要药物，预测复方的临床疗效，探索中药复方治疗痛经的用药规律。
1 资料来源
通过检索重庆维普数据库，收集自1987～2006年治疗痛经的中药复方176首，且药味完整，药量准确，疗效确切，每首复方的临床病例至少50例以上，病例总数17 079，建立数据库。
2 统计分析和结果
2.1 药物归类 痛经中药复方中主要有活血化瘀药、理气药和温经散寒药。按照《中药学》〔1〕归类方法，复方中活血化瘀类药物有18种：蒲黄、五灵脂、血见愁、花蕊石、三七、丹参、川芎、桃仁、红花、血竭、三棱、莪术、没药、乳香、水蛭、益母草、泽兰、延胡索；理气类药物19种：香附、木香、槟榔、乌药、柴胡、苏木、青皮、陈皮、枳实、沉香、丁香、王不留行、茺蔚子、枳壳、郁金、月季花、麝香、橘核、川楝子；温经散寒类药物11种：肉桂、附子、干姜、吴茱萸、艾叶、鹿角、桂枝、小茴香、白芥子、生姜、川椒。